SUBSCRIBE TO MY YOUTUBE CHANNEL & HELP SUPPORT BATS

CSIRO and Bats

facebook /

facebook /


facebook /

facebook /


Bat’s immunity may hold key to preventing future Ebola outbreaks

Posted: October 17, 2014 | Author: Nicholas Kachel | Filed under: Biosecurity, News, Tech-know |Tags: bats, ebola, ebola infection, ebola treatment |Leave a comment

By Michelle Baker, CSIRO

Bats can harbour viruses such as Ebola and don’t display clinical signs of disease. Image – Janelle Lugge

Bats are the natural host species for Ebola and a variety of viruses, many of which can be fatal when transmitted to humans. More than 100 viruses have been identified in bats and this number is rising each year.

African fruit bats first transmitted Ebola virus to primates and other species through contact with bat droppings, half-eaten fruit or bodily fluids of diseased bats. People are thought to have contracted the virus through contact with infected bats and primates. Subsequent person–to-person transmission occurs through direct contact with infected body fluids: blood, saliva, mucus, vomit, urine or faeces.

Interestingly, bats have the ability to harbour viruses such as Ebola and don’t display clinical signs of disease. Yet once the virus infects other species, it has the potential to cause widespread death and disease. How is it that bats are resistant to a disease that killsup to 90% of people it infects?
Ebola virus infection

The impact of Ebola virus in people is largely the result of the activation of the immune system, rather than the virus itself. During the initial stages of infection, Ebola shuts off the immune response to the virus, resulting in rapid viral replication and a delay in the production of antibodies.

The immune system is initiated only once the virus is out of control and then results in over-activation of the immune response. Although the role of the immune system is to eliminate the virus, when it is activated at extreme levels it becomes damaging to the host – in this case, an infected patient.

Like all haemorrhagic fevers, this results in widespread tissue damage, leading to internal and external bleeding, decreased kidney and liver function and ultimately, in many cases, death.
Therapies

The Ebola outbreak in West Africa is the largest ever recorded and is continuing to accelerate. Researchers and drug companies are racing to develop treatments and vaccines targeting the Zaire ebolavirus, the strain that is causing the current outbreak.

The first human trial to establish the safety of the vaccine and assess the immune responses of volunteers is underway. The researchers hope that by November there will be enough data to make an informed decision about whether to deploy the vaccine in Western Africa.

So far, studies in monkeys have demonstrated that the vaccine provides protective immunity for up to ten months.
Unlocking the bat immune system

Studying how bats control viral replication may unlock alternative mechanisms for tackling Ebola as well as other new and emerging infectious diseases. Increasing antimicrobial resistance of viruses, bacteria and fungi, for instance, is becoming a global concern and we need to think creatively to find solutions.

Bats and viruses have achieved an equilibrium that allows them to co-exist. Clues from studies of bat genomes have revealed differences in genes associated with the very early immune response that could help bats respond to infections. These genes appear to be evolving at a faster rate in bats compared with other species, providing evidence that they are likely co-evolving with the viruses that bats carry.

Functional differences in the immune system may also play a role. Unlike humans and mice, which activate their immune systems only in response to an infection, bats appear to have certain components of their immune system constantly switched on. This may allow bats to control viral replication much more efficiently compared with other species.

If we can redirect the immune responses of other species to behave in a similar manner to that of bats, the high death rate associated with diseases such as Ebola could be a thing of the past.

It’s tempting to look to culling as the answer to deal with bats as the natural hosts of Ebola. This suggestion was made during the spillover of Hendra virus from bats to horses in Australia. But it is not the answer; bats are an extremely successful group of mammals, making up 20% of all mammalian diversity. They are critical to ecosystems, with roles in insect control and pollination.

Rather than persecuting bats, we need to unravel the secrets of the success of this group of mammals. Understanding how bats control viral replication would not only assist in developing future therapeutics but may also help predict transmission events from bats into human and animal populations.

Michelle Baker receives funding from The Australian Research Council

This article was originally published on The Conversation.
Read the original article.

COMMENTS

BLOGGER: 1
Loading...
BatsRule!/\^._.^/\Help Save WildLife
Name

Articles,62,Audio,16,Backyard,13,Barbed Wire,23,Bat Art,39,Bat Books,74,Bat Box,26,Bat Clothing,14,Bat Issues,535,Bat Stamps,1,Bats for Children,32,Bats for the Home,67,Electrocution,8,Events,33,info on bats,509,Jackie Sparrow,22,Microbats,429,Misc,89,Netting,32,Newsletter,4,Promoting,130,Rehab,73,Rehab 2011,5,Rehab 2012,24,Rehab 2013,12,Rehab 2014,6,Rehab 2015,104,Rehab 2016,101,Rehab 2017,19,Release Cage,2,RESCUE,62,Rescue 2012,4,RESCUE 2013,18,RESCUE 2014,8,RESCUE 2015,24,Rescue 2016,12,RESCUE 2017,5,Rob Mies,11,Shooting,2,Vegetation,23,Video,265,Virus,117,WebSites-Bat,43,
ltr
item
Megabats and Microbats: CSIRO and Bats
CSIRO and Bats
CSIRO and Bats
https://1.bp.blogspot.com/-Kx8IwVGI-Z4/VZnveTE2fmI/AAAAAAABhIg/3tPdVaWj8og/s1600/csiro_n_bats_1.JPG
https://1.bp.blogspot.com/-Kx8IwVGI-Z4/VZnveTE2fmI/AAAAAAABhIg/3tPdVaWj8og/s72-c/csiro_n_bats_1.JPG
Megabats and Microbats
http://www.batsrule.info/2015/07/csiro-n-bats.html
http://www.batsrule.info/
http://www.batsrule.info/
http://www.batsrule.info/2015/07/csiro-n-bats.html
true
4238281482117672351
UTF-8
Loaded All Posts Not found any posts VIEW ALL Readmore Reply Cancel reply Delete By Home PAGES POSTS View All RECOMMENDED FOR YOU LABEL ARCHIVE SEARCH ALL POSTS Not found any post match with your request Back Home Sunday Monday Tuesday Wednesday Thursday Friday Saturday Sun Mon Tue Wed Thu Fri Sat January February March April May June July August September October November December Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec just now 1 minute ago $$1$$ minutes ago 1 hour ago $$1$$ hours ago Yesterday $$1$$ days ago $$1$$ weeks ago more than 5 weeks ago Followers Follow THIS CONTENT IS PREMIUM Please share to unlock Copy All Code Select All Code All codes were copied to your clipboard Can not copy the codes / texts, please press [CTRL]+[C] (or CMD+C with Mac) to copy